01 April 2019

Gene Transfer Improves Diabetes-linked Heart Ailment

Monday, April 01, 2019 0
Researchers with the VA San Diego Healthcare System and the University of California San Diego have shown that a gene transfer technique can combat heart dysfunction caused by diabetes.

Working with mice, the researchers showed that a single injection to promote the expression of the hormone urocortin 2 (UCn2) increased left ventricle function and improved how the body processed glucose. The study could lead to new clinical treatments for diabetes-related left ventricle dysfunction, they say.

The study appeared in the March 11, 2019, issue of Human Gene Therapy.

Dr. Kirk Hammond, the corresponding author on the study, explained that a single administration of an agent that both reduces blood sugar and increases heart function would be attractive to patients with diabetes. These patients often must adhere to complicated medical regimens, he explains, and therefore often have trouble complying with their care instructions.

Diabetes affects 9 percent of adults worldwide, including 29 million Americans. Nearly 25 percent of VA's patient population have diabetes. It increases the risk of cardiovascular disease, and death rates from heart disease are two to four times higher for adults with diabetes.

One major problem caused by diabetes is left ventricle dysfunction. The ventricles are the largest chambers of the heart. The right ventricle pumps blood to the lungs to receive oxygen, while the left ventricle pumps the blood to the rest of the body. Diabetes can cause the walls of the left ventricle to thicken and become fibrous, which stops it from pumping properly. Diabetes-related left ventricle dysfunction represents an unmet medical need, according to the researchers. As they explain, the prevalence of left ventricle dysfunction is increasing as diabetes rates increase globally.

Previous studies by the research team showed that UCn2 gene transfer increases cardiac function in normal mice and increases function in the failing heart (caused by heart attack). In the current study, the researchers wanted to see whether this same gene transfer technique would improve heart dysfunction caused by diabetes.

Gene transfer therapy involves positively changing how the body's genes operate using genetic material.

For this study, the researchers injected mice with a non-infectious virus called adeno-associated virus type 8, which carried the gene for UCn2. The virus vector goes mainly to the liver, where it manufactures UCn2. UCn2 is then released into the blood, where it interacts with specific receptors, which can improve heart function and increase glucose disposal. Glucose disposal refers to the uptake of glucose from the blood into tissues of the body.

To trigger diabetes, the researchers fed mice a diet of 45 percent fat, 35 percent carbohydrate, and 20 percent protein. This dietary balance is similar to the standard diet in Western countries such as the United States. A diet high in fats and sugars, as is common in a Wester diet, is linked with an increased risk of diabetes. Mice fed the Western diet for 30 weeks showed increased blood glucose and weight gain, along with reduced heart function compared with mice eating a diet lower in fat and sugar.

After 30 weeks on the diets, the mice received a single injection of the UCn2 gene transfer, or an injection of saline. Results show that the single injection of UCn2 gene transfer led to better left ventricle function after 10 weeks, compared with the mice given the saline placebo. Mice in the UCn2 group also had better glucose disposal, as well as reduced fat build-up in the liver.

Ten weeks after the injection, mice given the gene transfer had a 20-fold increase in UCn2 concentration in their blood. This increase was linked to reduced fasting blood glucose levels and better glucose tolerance, relative to the mice given saline. The increase in UCn2 led to increases of 38 percent for systolic and 33 percent for diastolic left ventricle function.

Although additional studies will be required, this therapy could lead to new treatment techniques for people with diabetes in clinical settings, according to the researchers. They call the possibility of a one-time treatment with enduring benefits on glucose disposal and left ventricle function "an attractive and unique therapeutic strategy."

Story Source:
Materials provided by Veterans Affairs Research Communications. Note: Content may be edited for style and length.

Journal Reference:
Young Chul Kim, Dimosthenis Giamouridis, N. Chin Lai, Tracy Guo, Bing Xia, Zhenxing Fu, Mei Hua Gao, H. Kirk Hammond. Urocortin 2 Gene Transfer Reduces the Adverse Effects of a Western Diet on Cardiac Function in Mice. Human Gene Therapy, 2019; DOI: 10.1089/hum.2018.150

Cite This Page:
Veterans Affairs Research Communications. "Gene transfer improves diabetes-linked heart ailment." ScienceDaily. ScienceDaily, 27 March 2019. <www.sciencedaily.com/releases/2019/03/190327174658.htm>.

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12 March 2019

Headaches will Disappear within 10 to 15 Minutes

Tuesday, March 12, 2019 0
Headache is an inevitable problem and almost every person often faces it. 

The headaches of the headache are unhealthy sometimes untouchable, and the person suffering from it is unable to do anything, even if a medicine or naturally headache reduces itself. However, today we are telling you a very easy way to get rid of this painful problem. 

For this you have to adopt a single pressure method. Chinese medicine is like a single-pressure acne-puncture, which can treat various complications through massage or stress on specific parts of the body. 

This method will take 30 seconds or minutes a minute.

First to sit on or relax in a comfortable condition to keep it cool and calm down. Now massage and stress with light hands on the following places. 

After the massage, headaches will disappear within 10 to 15 minutes.

11 March 2019

Alzheimer's-like Symptoms Reversed in Mice

Monday, March 11, 2019 0
Special diet with compounds contained in green tea and carrots restored working memory
A diet containing compounds found in green tea and carrots reversed Alzheimer's-like symptoms in mice genetically programmed to develop the disease, USC researchers say.

Researchers emphasize that the study, recently published in the Journal of Biological Chemistry, was in mice, and many mouse discoveries never translate into human treatments. Nevertheless, the findings lend credence to the idea that certain readily available, plant-based supplements might offer protection against dementia in humans.

"You don't have to wait 10 to 12 years for a designer drug to make it to market; you can make these dietary changes today," said senior author Terrence Town, a professor of physiology and neuroscience at the Keck School of Medicine of USC's Zilkha Neurogenetic Institute. "I find that very encouraging."

What's more, the study supports the idea that combination therapy, rather than a single magic bullet, may offer the best approach to treating the 5.7 million Americans living with Alzheimer's. Combination treatment is already the standard of care for diseases such as cancer, HIV infection and rheumatoid arthritis.

For this study, the researchers took a look at two compounds: EGCG, or epigallocatechin-3-gallate, a key ingredient in green tea, and FA, or ferulic acid, which is found in carrots, tomatoes, rice, wheat and oats.

The researchers randomly assigned 32 mice with Alzheimer's-like symptoms to one of four groups with an equal number of males and females. For comparison, each group also contained an equal number of healthy mice. For three months, the mice consumed a combination of EGCG and FA, or EGCG or FA only, or a placebo. The dosage was 30 mg per kilogram of body weight -- a dosage well-tolerated by humans and easily consumed as part of a healthy, plant-based diet or in the form supplements.

Before and after the three-month special diet, scientists ran the mice through a battery of neuropsychological tests that are roughly analogous to the thinking and memory tests that assess dementia in humans. Of particular note was a maze in the shape of a Y, which tests a mouse's spatial working memory -- a skill that humans use to find their way out of a building.

Healthy mice instinctively explore each arm of the Y maze, looking for food or a route to escape and entering the three arms in sequence more often than by chance alone. Impaired mice can't do this as well as their mentally healthy counterparts.

"After three months, combination treatment completely restored working memory and the Alzheimer's mice performed just as well as the healthy comparison mice," Town said.

How did it work? Town says one mechanism appeared to be the substances' ability to prevent amyloid precursor proteins from breaking up into the smaller proteins called amyloid beta that gum up Alzheimer patients' brains. In addition, the compounds appeared to reduce neuroinflammation and oxidative stress in the brain -- key aspects of Alzheimer's pathology in humans.

Town said he and his lab will continue exploring combination treatment, with a focus on plant-derived substances that inhibit production of the sticky amyloid beta plaques.

Story Source:
Materials provided by University of Southern California. Original written by Leigh Hopper. Note: Content may be edited for style and length.

Journal Reference:
Takashi Mori, Naoki Koyama, Jun Tan, Tatsuya Segawa, Masahiro Maeda, Terrence Town. Combined treatment with the phenolics (−)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice. Journal of Biological Chemistry, 2019; 294 (8): 2714 DOI: 10.1074/jbc.RA118.004280

Cite This Page:
University of Southern California. "Alzheimer's-like symptoms reversed in mice: Special diet with compounds contained in green tea and carrots restored working memory." ScienceDaily. ScienceDaily, 6 March 2019. <www.sciencedaily.com/releases/2019/03/190306133414.htm>.

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08 March 2019


Friday, March 08, 2019 0
This green smoothie in particular is going to be my motivator, to reach my fitness goals in the new year. It’s super easy to make, delicious, and overall extremely nourishing. It gives my body what it craves before and after every workout.

For us, this holiday season involved a lot of indulging – scrumptious no-bake desserts and need I say, tons of chocolate! But all goodies aside, it’s time to focus on better health and fitness (what my New Year’s resolution almost always comprises) and I like to set realistic goals for myself so that they’re more likely to be reachable.

A Green smoothie is meant to kickstart your metabolism into high gear, curve your appetite, fight off common colds and flus, and give you that high energy you need to start your day or your workout. Thank you antioxidants!

It also has the power to burn calories while you’re, well, not doing anything at all! And even relieves muscle aches and pains after a workout. That’s the ginger doing it’s job.

Not only does it burn fat, this smoothie helps your hair and nails grow fast. It’s a great drink for postpartum moms who notice their hair shedding more that usual (a depletion of nutrients in the body after birth, breast feeding, etc).

I’m throwing out the cake, the turtles, and all those goodies that we stuffed our faces with. It’s time to prepare for the warmer weather, better yet, vacation. The preparation starts now!

  • 2 handfuls baby spinach
  • 1 ripe banana
  • 1 cup almond milk
  • 1 cup frozen pineapple chunks
  • 1/2 tsp of ginger
  • 1 tbsp chia seeds

Place all of the ingredients into a blender. Pulse until smooth.
If smoothie is too thick, add water. If too thin, add ice.
Serve and garnish with a sprinkle of chia seeds, optional.

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07 March 2019

This is Murderer of Obesity!

Thursday, March 07, 2019 0

As indicated by such a significant number of looks into done by wellbeing specialists, the most ideal approach to get thinner is to speed your digestion. Now, what you cannot deny is that there are numerous normal nourishments that can help in boosting your digestion. In any case, on the off chance that you need to accomplish this, you should focus on the flavors that you devour. The eating regimen that pursues is known as the MURDERER OF OBESITY! 

Amid the procedure of weight reduction, yearning won't be surprising and extraordinary inclination. So as to maintain a strategic distance from explicit eating regimens with bringing down the calories consumption that produce the yearning feeling, you should join explicit herbs and include them in the sustenances you plan. While devouring these herbs, you will accelerate your digestion and this will enable you to consume the fat and dispose of weight. 

Coming up next are the most famous known flavors and herbs that we expend every day which are demonstrated to help your digestion: 
  • cinnamon, 
  • cayenne, 
  • cumin, 
  • ginger, 
  • garlic, 
  • dark pepper, 
  • dandelions, 
  • cardamom. 
This has additionally be demonstrated by an examination that was directed by certain researchers from the Medical Sciences University of Iran. With the end goal of this investigation look into, the members were isolated into two gatherings and every one of them was comprised of 44 ladies. The majority of the ladies had issues with their weight. 

For the following 90 days, the ladies from the two gatherings were eating well nourishment and they expended under 1000 calories for each day, yet there was one distinction in their eating regimen, and that is the flavors. The first of the gatherings expended three grams of powdered cumin consistently and more often than not they blended the cumin with 140 grams of yogurt, while the second gathering then again devoured a similar measure of yogurt yet without the cumin. 

Also, the primary gathering wiped out stoutness and consumed more fat than the second gathering of ladies. The ladies in gathering A lost 14.64% fat, while the ladies in gathering B have just lost 4.91% fat. 

As the flavor called cumin is known for being rich in Phytosterol, this reality clarified the outcomes for the gathering of ladies in the gathering An and the gathering B. As the zest cumin is known to be rich in Phytosterol, it has the capacity of counteracting maintenance of cholesterol develop in your body.

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Dust Affects Tooth Wear and Chewing Efficiency in Chimpanzees

Thursday, March 07, 2019 0
In their study, the researchers collected feces from chimpanzees living at Taï National Park, Ivory Coast, and analyzed chewing efficiency during dry and rainy periods. They found that increased dust loads during dry periods result in decreased chewing efficiency. Moreover, it was tested how dust affects tooth wear (surface texture) of the chimpanzees. The researchers found that consumption of dust covered foods created micrometer-scale surface texture features (e.g. fine furrows and dales) on cheek teeth while at the same time chewing was less intensive resulting in a lower amount of chews per food ingested and subsequently in larger mean fecal particle sizes.

What is more, the Leipzig researchers found evidence that abrasive loads from regionally (the West African subcontinent) acting periodical dust winds represent an ecological constraint on a local environment. The chimpanzees from the Taï forest are therefore one of the rarely described examples in African terrestrial environments where dust loads can be quantified and directly related to tooth wear.

In addition, the researchers explored the relationship between tooth wear and dietary composition using the long-term observation database on chimpanzee behavior of the Taï chimpanzee project and compiled observational data for feeding durations for the years 1993-2009. It was found that adult chimpanzees fed on 48 different plants and seven animal sources, most time on fruits and seeds, nuts, and leaves; and to a minor part on insects, plant pith and mammals. During the dry period chimpanzees increase feeding time on seeds and nuts, but reduce feeding on insects. Compared to males, females spent more time feeding on fruits, seeds, leaves, insects, and pith, but less on nuts, seeds and mammals.

"Understanding intraspecific feeding ecology and tooth wear patterns in chimpanzees is also a crucial first step for reconstructing the paleoecology of extinct hominins," said Ellen Schulz-Kornas, who led the study at the former Max Planck Weizmann Center for Integrative Archaeology and Anthropology at the MPI-EVA in Leipzig. "When considering the findings of the present study it is conceivable that dust may have also triggered a decreased chewing efficiency, leading to dietary-physiological stress on the digestive system of fossil species," Schulz-Kornas pointed out. "This may be especially important in seasonally fluctuating environments with an increased bias towards dry climate phases like for example in the South African early hominin record between 3.2 and 1.3 Million years ago," concluded Schulz-Kornas.

Story Source:
Materials provided by Max Planck Institute for Evolutionary Anthropology. Note: Content may be edited for style and length.

Journal Reference:
Ellen Schulz-Kornas, Julia Stuhlträger, Marcus Clauss, Roman M. Wittig, Kornelius Kupczik. Dust affects chewing efficiency and tooth wear in forest dwelling Western chimpanzees (Pan troglodytes verus). American Journal of Physical Anthropology, 2019; DOI: 10.1002/ajpa.23808

Cite This Page:
Max Planck Institute for Evolutionary Anthropology. "Dust affects tooth wear and chewing efficiency in chimpanzees: Increased dust loads result in decreased chewing efficiency in chimpanzees." ScienceDaily. ScienceDaily, 6 March 2019. <www.sciencedaily.com/releases/2019/03/190306100547.htm>.

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06 March 2019

Soda, Sugar-Sweetened Beverages Linked To More Severe Symptoms For People With Multiple Sclerosis

Wednesday, March 06, 2019 0
For people with multiple sclerosis (MS), drinking around 290 calories per day of soda or other sugar-sweetened beverages, or the equivalent of about two cans of non-diet soda, may be tied to more severe symptoms and a higher level of disability compared to people with MS who seldom consume sugar-sweetened beverages, according to a preliminary study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4 to 10, 2019. People who seldom drank sugar-sweetened beverages consumed an average of seven calories in sugar-sweetened beverages per day, or the equivalent of one-and-a-half cans of non-diet soda per month. Soda and other sweet beverages were the only type of food that was related to MS symptoms in the study.

"MS patients often want to know how diet and specific foods can affect the progression of their disease," said study author Elisa Meier-Gerdingh, MD, of St. Josef Hospital in Bochum, Germany, and a member of the American Academy of Neurology. "While we did not find a link with overall diet, interestingly, we did find a link with those who drank sodas, flavored juices and sweetened teas and coffees."

The study involved 135 people with MS. Participants completed a questionnaire about their diet. Researchers then looked at how close each participants' diet was to the Dietary Approaches to Stop Hypertension (DASH) diet. The DASH diet recommends whole grains, fruits and vegetables, low-fat dairy products, lean meats, poultry and fish, and nuts and legumes and limits foods that are high in saturated fat and sugar.

"We chose to study the DASH diet because adherence to the DASH diet is associated with lower risk of other chronic diseases like high blood pressure, diabetes and cardiovascular diseases," said Meier-Gerdingh.

Researchers also measured the participants' level of disability using the Expanded Disability Status Scale, a common method to quantify disability ranging from 0, no symptoms, to 10 points, death due to MS. A total of 30 participants had severe disability.

Overall, researchers did not find a link between what participants ate and their level of disability.

For soda and sugar-sweetened beverages, the participants were divided into five groups based on how much they drank. The people in the top group drank an average of 290 calories of sugar-sweetened beverages per day, while the lowest group seldom drank sugar-sweetened beverages.

The study found that participants who consumed the largest amounts of sugar-sweetened beverages were five times more likely to have severe disability than people who seldom drank sugar-sweetened beverages. Of the 34 people in the top group, 12 had severe disability, compared to 4 of the 34 people in the bottom group. The top group had on average a disability score of 4.1 points, while the bottom group had an average of 3.4 points.

"While these results need to be confirmed by larger studies that follow people over a long period of time, and the results do not show that soda and sugar-sweetened beverages cause more severe disability, we do know that sodas have no nutritional value and people with MS may want to consider reducing or eliminating them from their diet," Meier-Gerdingh said.

Limitations of the study include the relatively small number of participants. The study also assessed participants' diets and sugar-sweetened beverages at the same time as disability, so it is not possible to distinguish whether it is actually an aspect of diet, like sugar-sweetened beverages, that contributes to higher disability or whether more severe disease impacts a person's ability to have a healthy diet.

Additional studies are needed to evaluate whether sugar-sweetened beverages affect the course of the disease.

Story Source:
Materials provided by American Academy of Neurology. Note: Content may be edited for style and length.

Cite This Page:
American Academy of Neurology. "Soda, sugar-sweetened beverages linked to more severe symptoms for people with multiple sclerosis." ScienceDaily. ScienceDaily, 5 March 2019. <www.sciencedaily.com/releases/2019/03/190305162008.htm>.

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26 February 2019

New Parents Face 6 Years of Disrupted Sleep

Tuesday, February 26, 2019 0
The birth of a child has drastic short-term effects on new mothers' sleep, particularly during the first three months after birth. Researchers at the University of Warwick have also found sleep duration and satisfaction is decreased up to six years after giving birth for both parents.

A new study by researchers from the University of Warwick shows that after birth of the first child and up to 6 years after birth mothers and fathers sleep duration and sleep satisfaction do not fully recover to the levels before pregnancy.

In the paper 'Long-term effects of pregnancy and childbirth on sleep satisfaction and duration of first-time and experienced mothers and fathers', a collaboration with the German Institute for Economic Research and the West Virginia University studied sleep in 4,659 parents who had a child between 2008 and 2015.

During these years parents also reported on their sleep in yearly interviews. In the first 3 months after birth mothers slept on average 1 hour less than before pregnancy while fathers sleep duration decreased by approximately 15 minutes.

Dr Sakari Lemola, from the Department of Psychology at the University of Warwick comments:

"Women tend to experience more sleep disruption than men after the birth of a child reflecting that mothers are still more often in the role of the primary caregiver than fathers"

However, when the children were 4-6 years old sleep duration was still about 20 minutes shorter in mothers and 15 minutes shorter in fathers compared to their sleep duration before pregnancy. A similar time course was also observed for their satisfaction with sleep.

Sleep effects were more pronounced in first-time parents compared with experienced parents. In the first half a year after birth the sleep effects were also somewhat stronger in breastfeeding compared with bottle-feeding mothers.

Higher household income and psychosocial factors such as dual vs. single parenting did not appear to protect against these changes in sleep after childbirth.

Dr Sakari Lemola, from the Department of Psychology at the University of Warwick comments:

"While having children is a major source of joy for most parents it is possible that increased demands and responsibilities associated with the role as a parent lead to shorter sleep and decreased sleep quality even up to 6 years after birth of the first child."

Story Source:
Materials provided by University of Warwick. Note: Content may be edited for style and length.

Journal Reference:
Richter, D., Krämer, M.D., Tang, N.K.Y., Montgomery-Downs, H.E., & Lemola, S. Long-term effects of pregnancy and childbirth on sleep satisfaction and duration of first-time and experienced mothers and fathers. Sleep, 2019 DOI: 10.1093/sleep/zsz015/5289255

Cite This Page:
University of Warwick. "New parents face 6 years of disrupted sleep." ScienceDaily. ScienceDaily, 25 February 2019. <www.sciencedaily.com/releases/2019/02/190225192116.htm>.

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